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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1980 1
1984 1
1985 1
1987 1
1988 1
1989 1
1990 1
1991 1
1992 1
1993 4
1994 1
1995 1
1996 2
1997 6
1998 3
1999 4
2000 6
2001 5
2002 7
2003 1
2004 2
2005 6
2006 4
2007 5
2008 3
2009 5
2010 2
2011 6
2012 3
2013 5
2014 5
2015 4
2016 8
2017 4
2018 15
2019 25
2020 13
2021 3
2022 14
2023 9
2024 7

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187 results

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Page 1
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.
Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, Halle A, Petzold GC. Reichenbach N, et al. EMBO Mol Med. 2019 Feb;11(2):e9665. doi: 10.15252/emmm.201809665. EMBO Mol Med. 2019. PMID: 30617153 Free PMC article.
We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, is activated in an AD mouse model and human AD Therefore, using a conditional knockout approach, we deleted Stat3 specifically in ast …
We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, …
Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors.
Milbury CA, Creeden J, Yip WK, Smith DL, Pattani V, Maxwell K, Sawchyn B, Gjoerup O, Meng W, Skoletsky J, Concepcion AD, Tang Y, Bai X, Dewal N, Ma P, Bailey ST, Thornton J, Pavlick DC, Frampton GM, Lieber D, White J, Burns C, Vietz C. Milbury CA, et al. PLoS One. 2022 Mar 16;17(3):e0264138. doi: 10.1371/journal.pone.0264138. eCollection 2022. PLoS One. 2022. PMID: 35294956 Free PMC article.
The analytical validation included several in-depth evaluations of F1CDx assay performance including limit of detection (LoD), limit of blank (LoB), precision, and orthogonal concordance for SVs (including base substitutions [SUBs] and insertions/deletions [INDELs]) …
The analytical validation included several in-depth evaluations of F1CDx assay performance including limit of detection (LoD), limit of b …
Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.
Vendelova E, Ashour D, Blank P, Erhard F, Saliba AE, Kalinke U, Lutz MB. Vendelova E, et al. Front Immunol. 2018 Feb 28;9:333. doi: 10.3389/fimmu.2018.00333. eCollection 2018. Front Immunol. 2018. PMID: 29541071 Free PMC article. Review.
During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, and Treg activity. All of these mechanisms help to prevent autoimmune diseases or other hyperreactivities. ...
During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, a …
Modernizing the World Health Organization List of Essential Medicines for Preventing and Controlling Cardiovascular Diseases.
Kishore SP, Blank E, Heller DJ, Patel A, Peters A, Price M, Vidula M, Fuster V, Onuma O, Huffman MD, Vedanthan R. Kishore SP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):564-574. doi: 10.1016/j.jacc.2017.11.056. J Am Coll Cardiol. 2018. PMID: 29406862 Free article. Review.
Here, we describe our efforts to modernize the EML for global CVD prevention and control. We review the recent history of applications to add, delete, and change indications for CVD medicines, with the aim of aligning the list with contemporary clinical practice guidelines …
Here, we describe our efforts to modernize the EML for global CVD prevention and control. We review the recent history of applications to ad …
Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown.
Blank M, Sims NA. Blank M, et al. Curr Osteoporos Rep. 2019 Oct;17(5):270-280. doi: 10.1007/s11914-019-00524-y. Curr Osteoporos Rep. 2019. PMID: 31401710 Review.
Early-stage deletion in osteoblasts leads to osteoblast apoptosis, delayed initiation of mineralization, and increased bone flexibility. Deletion later in the lineage targeted to osteocytes leads to a brittle bone phenotype and increased osteocyte autophagy. ...
Early-stage deletion in osteoblasts leads to osteoblast apoptosis, delayed initiation of mineralization, and increased bone flexibili …
Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae.
Liu Y, Hammer LA, Daamen J, Stork M, Egilmez NK, Russell MW. Liu Y, et al. mSphere. 2023 Feb 21;8(1):e0038822. doi: 10.1128/msphere.00388-22. Epub 2022 Dec 20. mSphere. 2023. PMID: 36537786 Free PMC article.
Female and male mice were immunized i.n. with gonococcal OMVs plus IL-12 ms or blank microspheres (blank ms). Responses to i.n. immunization were similar to those with i.vag. immunization, with serum IgG, salivary IgA, and vaginal IgG and IgA antigonococcal antibodi …
Female and male mice were immunized i.n. with gonococcal OMVs plus IL-12 ms or blank microspheres (blank ms). Responses to i.n …
Oncolytic virus Ad-TD-nsIL-12 inhibits glioma growth and reprograms the tumor immune microenvironment.
Li S, Guo Y, Ning W, Chen Y, Xu J, Zhao C, Wang J, Qu Y, Zhang M, Wang P, Wang Y, Wang S, Zhang H. Li S, et al. Life Sci. 2024 Jan 1;336:122254. doi: 10.1016/j.lfs.2023.122254. Epub 2023 Nov 17. Life Sci. 2024. PMID: 37977355
AIMS: Gliomas are the most common central nervous system malignancies, with limited therapeutic options and poor prognosis, which are primarily attributed to the "immune desert" microenvironment. Previously, we constructed a three-gene-deleted oncolytic adenovirus ( …
AIMS: Gliomas are the most common central nervous system malignancies, with limited therapeutic options and poor prognosis, which are primar …
Genetic Cell-Surface Modification for Optimized Foam Fractionation.
Blesken CC, Bator I, Eberlein C, Heipieper HJ, Tiso T, Blank LM. Blesken CC, et al. Front Bioeng Biotechnol. 2020 Oct 29;8:572892. doi: 10.3389/fbioe.2020.572892. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 33195133 Free PMC article.
To diminish the accumulation of bacteria at the gas-liquid interface, we deleted genes encoding cell-surface structures, focusing on hydrophobic proteins present on P. putida KT2440. ...
To diminish the accumulation of bacteria at the gas-liquid interface, we deleted genes encoding cell-surface structures, focusing on …
Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440.
Li WJ, Narancic T, Kenny ST, Niehoff PJ, O'Connor K, Blank LM, Wierckx N. Li WJ, et al. Front Microbiol. 2020 Mar 17;11:382. doi: 10.3389/fmicb.2020.00382. eCollection 2020. Front Microbiol. 2020. PMID: 32256468 Free PMC article.
Initially, 1,4-butanediol is oxidized to 4-hydroxybutyrate, in which the highly expressed dehydrogenase enzymes encoded within the PP_2674-2680 ped gene cluster play an essential role. The resulting 4-hydroxybutyrate can be metabolized through three possible pathways: (i) …
Initially, 1,4-butanediol is oxidized to 4-hydroxybutyrate, in which the highly expressed dehydrogenase enzymes encoded within the PP_2674-2 …
Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report.
DeWire M, Lazow M, Campagne O, Leach J, Fuller C, Senthil Kumar S, Stanek J, de Blank P, Hummel TR, Pillay-Smiley N, Salloum R, Stevenson CB, Baxter P, Gass D, Goldman S, Leary SES, Carle A, Mikael L, Crabtree D, Chaney B, Lane A, Drissi R, Stewart CF, Fouladi M. DeWire M, et al. Neurooncol Adv. 2022 Apr 16;4(1):vdac055. doi: 10.1093/noajnl/vdac055. eCollection 2022 Jan-Dec. Neurooncol Adv. 2022. PMID: 35611273 Free PMC article.
Two longer survivors had tumor molecular profiling identifying CDKN2A/B deletion and CDK4 overexpression. CONCLUSION: The combination of ribociclib and everolimus following radiotherapy in children with newly diagnosed DIPG and HGG was well tolerated, with a RP2D of riboci …
Two longer survivors had tumor molecular profiling identifying CDKN2A/B deletion and CDK4 overexpression. CONCLUSION: The combination …
187 results